Biodetection Assays, Genomics/Proteomics, Protein Structure, Immune Therapy

UVa

How can the explosion of comparative genomic information be applied to the understanding of protein structural evolution, and the development of new drug targets or protein-engineered drugs?

How can proteomics and the advancement of mass spectrometry be applied to the dissection of protein complexes in cell signaling, the treatment of human melanoma by gene therapy, and the identification of novel sperm antigens? How can mass spectrometry be integrated with chemical biology to understand metabolic regulation? What are the molecular mechanisms of innate immunity and antiviral defense. How can the mechanisms controlling stem cell fate be monitored at the single cell level?

How can gene microarray technology be used to identify candidate cancer disease genes, and genes involved in arteriolar network remodeling?

How can miniaturized electrophoretic technology on microchips use gene amplification approaches to develop rapid new microfluidic assays? How can microfluidic culture systems be used to learn about the dynamics of the inflammatory cascade? How can modern analytical approaches be applied to the zeptomolar detection of neuropeptides and neuromodulators?

How can molecule-based imaging technologies and ultrasound specify early disease onset, treatment, and underlie new drug development?

How does the brain develop as a genetic mosaic? What is the role of chromatin regulatory networks in normal and malignant development? How are biopolymers transported across biological membranes?

Faculty engaged in this research

Adli

Braciale

Brown

Columbus

Engelhard

Hahn

Hossack

Hsu

Kelly

Pompano

Venton [video]

Zimmer

Zunder